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Differentiate w.r.t. a
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\frac{\left(-12\right)^{1}a^{6}b^{6}}{\left(-3\right)^{1}a^{2}b^{4}}
Use the rules of exponents to simplify the expression.
\frac{\left(-12\right)^{1}}{\left(-3\right)^{1}}a^{6-2}b^{6-4}
To divide powers of the same base, subtract the denominator's exponent from the numerator's exponent.
\frac{\left(-12\right)^{1}}{\left(-3\right)^{1}}a^{4}b^{6-4}
Subtract 2 from 6.
\frac{\left(-12\right)^{1}}{\left(-3\right)^{1}}a^{4}b^{2}
Subtract 4 from 6.
4a^{4}b^{2}
Divide -12 by -3.
\frac{\mathrm{d}}{\mathrm{d}a}(\left(-\frac{12b^{6}}{-3b^{4}}\right)a^{6-2})
To divide powers of the same base, subtract the denominator's exponent from the numerator's exponent.
\frac{\mathrm{d}}{\mathrm{d}a}(4b^{2}a^{4})
Do the arithmetic.
4\times 4b^{2}a^{4-1}
The derivative of a polynomial is the sum of the derivatives of its terms. The derivative of a constant term is 0. The derivative of ax^{n} is nax^{n-1}.
16b^{2}a^{3}
Do the arithmetic.