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Evaluate
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Differentiate w.r.t. x
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\frac{\left(-10\right)^{1}x^{8}y^{13}}{2^{1}x^{5}y^{10}}
Use the rules of exponents to simplify the expression.
\frac{\left(-10\right)^{1}}{2^{1}}x^{8-5}y^{13-10}
To divide powers of the same base, subtract the denominator's exponent from the numerator's exponent.
\frac{\left(-10\right)^{1}}{2^{1}}x^{3}y^{13-10}
Subtract 5 from 8.
\frac{\left(-10\right)^{1}}{2^{1}}x^{3}y^{3}
Subtract 10 from 13.
-5x^{3}y^{3}
Divide -10 by 2.
\frac{\mathrm{d}}{\mathrm{d}x}(\left(-\frac{10y^{13}}{2y^{10}}\right)x^{8-5})
To divide powers of the same base, subtract the denominator's exponent from the numerator's exponent.
\frac{\mathrm{d}}{\mathrm{d}x}(\left(-5y^{3}\right)x^{3})
Do the arithmetic.
3\left(-5y^{3}\right)x^{3-1}
The derivative of a polynomial is the sum of the derivatives of its terms. The derivative of a constant term is 0. The derivative of ax^{n} is nax^{n-1}.
\left(-15y^{3}\right)x^{2}
Do the arithmetic.