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Differentiate w.r.t. p
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\frac{-5^{2}\left(p^{2}\right)^{2}\left(q^{-3}\right)^{2}}{10pr^{-4}}\times \frac{2\sqrt[3]{pr}}{q^{3}}
Expand \left(5p^{2}q^{-3}\right)^{2}.
\frac{-5^{2}p^{4}\left(q^{-3}\right)^{2}}{10pr^{-4}}\times \frac{2\sqrt[3]{pr}}{q^{3}}
To raise a power to another power, multiply the exponents. Multiply 2 and 2 to get 4.
\frac{-5^{2}p^{4}q^{-6}}{10pr^{-4}}\times \frac{2\sqrt[3]{pr}}{q^{3}}
To raise a power to another power, multiply the exponents. Multiply -3 and 2 to get -6.
\frac{-25p^{4}q^{-6}}{10pr^{-4}}\times \frac{2\sqrt[3]{pr}}{q^{3}}
Calculate 5 to the power of 2 and get 25.
\frac{\left(-25p^{4}q^{-6}\right)\times 2\sqrt[3]{pr}}{10pr^{-4}q^{3}}
Multiply \frac{-25p^{4}q^{-6}}{10pr^{-4}} times \frac{2\sqrt[3]{pr}}{q^{3}} by multiplying numerator times numerator and denominator times denominator.
\frac{\left(-25q^{-6}p^{4}\right)\sqrt[3]{pr}}{5r^{-4}pq^{3}}
Cancel out 2 in both numerator and denominator.
\frac{-25q^{-6}\sqrt[3]{pr}p^{4}}{5r^{-4}pq^{3}}
Factor the expressions that are not already factored.
\frac{-5q^{-6}\sqrt[3]{pr}p^{3}}{r^{-4}q^{3}}
Cancel out 5p in both numerator and denominator.
\frac{-5\sqrt[3]{pr}p^{3}}{r^{-4}q^{9}}
To divide powers of the same base, subtract the numerator's exponent from the denominator's exponent.
\frac{-5\sqrt[3]{r}p^{\frac{10}{3}}}{r^{-4}q^{9}}
Expand the expression.
\frac{-5p^{\frac{10}{3}}r^{\frac{13}{3}}}{q^{9}}
To divide powers of the same base, subtract the denominator's exponent from the numerator's exponent.