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Differentiate w.r.t. x
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\left(x^{2}\right)^{4}\times \frac{1}{x^{20}}
Use the rules of exponents to simplify the expression.
x^{2\times 4}x^{20\left(-1\right)}
To raise a power to another power, multiply the exponents.
x^{8}x^{20\left(-1\right)}
Multiply 2 times 4.
x^{8}x^{-20}
Multiply 20 times -1.
x^{8-20}
To multiply powers of the same base, add their exponents.
x^{-12}
Add the exponents 8 and -20.
\frac{\mathrm{d}}{\mathrm{d}x}(\frac{x^{8}}{x^{20}})
To raise a power to another power, multiply the exponents. Multiply 2 and 4 to get 8.
\frac{\mathrm{d}}{\mathrm{d}x}(\frac{1}{x^{12}})
Rewrite x^{20} as x^{8}x^{12}. Cancel out x^{8} in both numerator and denominator.
-\left(x^{12}\right)^{-1-1}\frac{\mathrm{d}}{\mathrm{d}x}(x^{12})
If F is the composition of two differentiable functions f\left(u\right) and u=g\left(x\right), that is, if F\left(x\right)=f\left(g\left(x\right)\right), then the derivative of F is the derivative of f with respect to u times the derivative of g with respect to x, that is, \frac{\mathrm{d}}{\mathrm{d}x}(F)\left(x\right)=\frac{\mathrm{d}}{\mathrm{d}x}(f)\left(g\left(x\right)\right)\frac{\mathrm{d}}{\mathrm{d}x}(g)\left(x\right).
-\left(x^{12}\right)^{-2}\times 12x^{12-1}
The derivative of a polynomial is the sum of the derivatives of its terms. The derivative of a constant term is 0. The derivative of ax^{n} is nax^{n-1}.
-12x^{11}\left(x^{12}\right)^{-2}
Simplify.