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\frac{\left(x+2y\right)\left(x+4y\right)\left(x^{2}-10xy+25y^{2}\right)}{\left(x-2y\right)\left(x-5y\right)\left(x^{2}-16y^{2}\right)}
Divide \frac{\left(x+2y\right)\left(x+4y\right)}{\left(x-2y\right)\left(x-5y\right)} by \frac{x^{2}-16y^{2}}{x^{2}-10xy+25y^{2}} by multiplying \frac{\left(x+2y\right)\left(x+4y\right)}{\left(x-2y\right)\left(x-5y\right)} by the reciprocal of \frac{x^{2}-16y^{2}}{x^{2}-10xy+25y^{2}}.
\frac{\left(x+2y\right)\left(x+4y\right)\left(x-5y\right)^{2}}{\left(x-5y\right)\left(x-4y\right)\left(x-2y\right)\left(x+4y\right)}
Factor the expressions that are not already factored.
\frac{\left(x-5y\right)\left(x+2y\right)}{\left(x-4y\right)\left(x-2y\right)}
Cancel out \left(x-5y\right)\left(x+4y\right) in both numerator and denominator.
\frac{x^{2}-3xy-10y^{2}}{x^{2}-6xy+8y^{2}}
Expand the expression.
\frac{\left(x+2y\right)\left(x+4y\right)\left(x^{2}-10xy+25y^{2}\right)}{\left(x-2y\right)\left(x-5y\right)\left(x^{2}-16y^{2}\right)}
Divide \frac{\left(x+2y\right)\left(x+4y\right)}{\left(x-2y\right)\left(x-5y\right)} by \frac{x^{2}-16y^{2}}{x^{2}-10xy+25y^{2}} by multiplying \frac{\left(x+2y\right)\left(x+4y\right)}{\left(x-2y\right)\left(x-5y\right)} by the reciprocal of \frac{x^{2}-16y^{2}}{x^{2}-10xy+25y^{2}}.
\frac{\left(x+2y\right)\left(x+4y\right)\left(x-5y\right)^{2}}{\left(x-5y\right)\left(x-4y\right)\left(x-2y\right)\left(x+4y\right)}
Factor the expressions that are not already factored.
\frac{\left(x-5y\right)\left(x+2y\right)}{\left(x-4y\right)\left(x-2y\right)}
Cancel out \left(x-5y\right)\left(x+4y\right) in both numerator and denominator.
\frac{x^{2}-3xy-10y^{2}}{x^{2}-6xy+8y^{2}}
Expand the expression.