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\frac{4^{4}x^{4}\left(y^{2}\right)^{4}z^{4}}{\left(-2x^{2}yz^{3}\right)^{3}}
Expand \left(4xy^{2}z\right)^{4}.
\frac{4^{4}x^{4}y^{8}z^{4}}{\left(-2x^{2}yz^{3}\right)^{3}}
To raise a power to another power, multiply the exponents. Multiply 2 and 4 to get 8.
\frac{256x^{4}y^{8}z^{4}}{\left(-2x^{2}yz^{3}\right)^{3}}
Calculate 4 to the power of 4 and get 256.
\frac{256x^{4}y^{8}z^{4}}{\left(-2\right)^{3}\left(x^{2}\right)^{3}y^{3}\left(z^{3}\right)^{3}}
Expand \left(-2x^{2}yz^{3}\right)^{3}.
\frac{256x^{4}y^{8}z^{4}}{\left(-2\right)^{3}x^{6}y^{3}\left(z^{3}\right)^{3}}
To raise a power to another power, multiply the exponents. Multiply 2 and 3 to get 6.
\frac{256x^{4}y^{8}z^{4}}{\left(-2\right)^{3}x^{6}y^{3}z^{9}}
To raise a power to another power, multiply the exponents. Multiply 3 and 3 to get 9.
\frac{256x^{4}y^{8}z^{4}}{-8x^{6}y^{3}z^{9}}
Calculate -2 to the power of 3 and get -8.
\frac{32y^{5}}{-x^{2}z^{5}}
Cancel out 8y^{3}x^{4}z^{4} in both numerator and denominator.
\frac{-32y^{5}}{x^{2}z^{5}}
Cancel out -1 in both numerator and denominator.
\frac{4^{4}x^{4}\left(y^{2}\right)^{4}z^{4}}{\left(-2x^{2}yz^{3}\right)^{3}}
Expand \left(4xy^{2}z\right)^{4}.
\frac{4^{4}x^{4}y^{8}z^{4}}{\left(-2x^{2}yz^{3}\right)^{3}}
To raise a power to another power, multiply the exponents. Multiply 2 and 4 to get 8.
\frac{256x^{4}y^{8}z^{4}}{\left(-2x^{2}yz^{3}\right)^{3}}
Calculate 4 to the power of 4 and get 256.
\frac{256x^{4}y^{8}z^{4}}{\left(-2\right)^{3}\left(x^{2}\right)^{3}y^{3}\left(z^{3}\right)^{3}}
Expand \left(-2x^{2}yz^{3}\right)^{3}.
\frac{256x^{4}y^{8}z^{4}}{\left(-2\right)^{3}x^{6}y^{3}\left(z^{3}\right)^{3}}
To raise a power to another power, multiply the exponents. Multiply 2 and 3 to get 6.
\frac{256x^{4}y^{8}z^{4}}{\left(-2\right)^{3}x^{6}y^{3}z^{9}}
To raise a power to another power, multiply the exponents. Multiply 3 and 3 to get 9.
\frac{256x^{4}y^{8}z^{4}}{-8x^{6}y^{3}z^{9}}
Calculate -2 to the power of 3 and get -8.
\frac{32y^{5}}{-x^{2}z^{5}}
Cancel out 8y^{3}x^{4}z^{4} in both numerator and denominator.
\frac{-32y^{5}}{x^{2}z^{5}}
Cancel out -1 in both numerator and denominator.