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Differentiate w.r.t. a
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\frac{1}{\left(2a\right)^{5}}
Rewrite \left(2a\right)^{5} as \left(2a\right)^{0}\times \left(2a\right)^{5}. Cancel out \left(2a\right)^{0} in both numerator and denominator.
\frac{1}{2^{5}a^{5}}
Expand \left(2a\right)^{5}.
\frac{1}{32a^{5}}
Calculate 2 to the power of 5 and get 32.
\frac{\mathrm{d}}{\mathrm{d}a}(\frac{1}{\left(2a\right)^{5}})
Rewrite \left(2a\right)^{5} as \left(2a\right)^{0}\times \left(2a\right)^{5}. Cancel out \left(2a\right)^{0} in both numerator and denominator.
\frac{\mathrm{d}}{\mathrm{d}a}(\frac{1}{2^{5}a^{5}})
Expand \left(2a\right)^{5}.
\frac{\mathrm{d}}{\mathrm{d}a}(\frac{1}{32a^{5}})
Calculate 2 to the power of 5 and get 32.
-\left(32a^{5}\right)^{-1-1}\frac{\mathrm{d}}{\mathrm{d}a}(32a^{5})
If F is the composition of two differentiable functions f\left(u\right) and u=g\left(x\right), that is, if F\left(x\right)=f\left(g\left(x\right)\right), then the derivative of F is the derivative of f with respect to u times the derivative of g with respect to x, that is, \frac{\mathrm{d}}{\mathrm{d}x}(F)\left(x\right)=\frac{\mathrm{d}}{\mathrm{d}x}(f)\left(g\left(x\right)\right)\frac{\mathrm{d}}{\mathrm{d}x}(g)\left(x\right).
-\left(32a^{5}\right)^{-2}\times 5\times 32a^{5-1}
The derivative of a polynomial is the sum of the derivatives of its terms. The derivative of a constant term is 0. The derivative of ax^{n} is nax^{n-1}.
-160a^{4}\times \left(32a^{5}\right)^{-2}
Simplify.