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\frac{-64\times 72}{2^{2}\times 3^{3}\left(-8\right)^{2}}
Calculate -4 to the power of 3 and get -64.
\frac{-4608}{2^{2}\times 3^{3}\left(-8\right)^{2}}
Multiply -64 and 72 to get -4608.
\frac{-4608}{4\times 3^{3}\left(-8\right)^{2}}
Calculate 2 to the power of 2 and get 4.
\frac{-4608}{4\times 27\left(-8\right)^{2}}
Calculate 3 to the power of 3 and get 27.
\frac{-4608}{108\left(-8\right)^{2}}
Multiply 4 and 27 to get 108.
\frac{-4608}{108\times 64}
Calculate -8 to the power of 2 and get 64.
\frac{-4608}{6912}
Multiply 108 and 64 to get 6912.
-\frac{2}{3}
Reduce the fraction \frac{-4608}{6912} to lowest terms by extracting and canceling out 2304.