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Differentiate w.r.t. x
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\frac{x}{\left(x+8\right)x^{3}}
Express \frac{\frac{x}{x+8}}{x^{3}} as a single fraction.
\frac{1}{\left(x+8\right)x^{2}}
Cancel out x in both numerator and denominator.
\frac{1}{x^{3}+8x^{2}}
Use the distributive property to multiply x+8 by x^{2}.
\frac{\mathrm{d}}{\mathrm{d}x}(\frac{x}{\left(x+8\right)x^{3}})
Express \frac{\frac{x}{x+8}}{x^{3}} as a single fraction.
\frac{\mathrm{d}}{\mathrm{d}x}(\frac{1}{\left(x+8\right)x^{2}})
Cancel out x in both numerator and denominator.
\frac{\mathrm{d}}{\mathrm{d}x}(\frac{1}{x^{3}+8x^{2}})
Use the distributive property to multiply x+8 by x^{2}.
-\left(x^{3}+8x^{2}\right)^{-1-1}\frac{\mathrm{d}}{\mathrm{d}x}(x^{3}+8x^{2})
If F is the composition of two differentiable functions f\left(u\right) and u=g\left(x\right), that is, if F\left(x\right)=f\left(g\left(x\right)\right), then the derivative of F is the derivative of f with respect to u times the derivative of g with respect to x, that is, \frac{\mathrm{d}}{\mathrm{d}x}(F)\left(x\right)=\frac{\mathrm{d}}{\mathrm{d}x}(f)\left(g\left(x\right)\right)\frac{\mathrm{d}}{\mathrm{d}x}(g)\left(x\right).
-\left(x^{3}+8x^{2}\right)^{-2}\left(3x^{3-1}+2\times 8x^{2-1}\right)
The derivative of a polynomial is the sum of the derivatives of its terms. The derivative of a constant term is 0. The derivative of ax^{n} is nax^{n-1}.
\left(x^{3}+8x^{2}\right)^{-2}\left(-3x^{2}-16x^{1}\right)
Simplify.
\left(x^{3}+8x^{2}\right)^{-2}\left(-3x^{2}-16x\right)
For any term t, t^{1}=t.