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\frac{\frac{2x^{2}-5x-3}{x-4}}{\frac{x-3}{\left(x^{2}-16\right)\left(3-x\right)}}
Multiply \frac{x-3}{x^{2}-16} times \frac{1}{3-x} by multiplying numerator times numerator and denominator times denominator.
\frac{\frac{2x^{2}-5x-3}{x-4}}{\frac{-\left(-x+3\right)}{\left(-x+3\right)\left(x^{2}-16\right)}}
Extract the negative sign in x-3.
\frac{\frac{2x^{2}-5x-3}{x-4}}{\frac{-1}{x^{2}-16}}
Cancel out -x+3 in both numerator and denominator.
\frac{\left(2x^{2}-5x-3\right)\left(x^{2}-16\right)}{\left(x-4\right)\left(-1\right)}
Divide \frac{2x^{2}-5x-3}{x-4} by \frac{-1}{x^{2}-16} by multiplying \frac{2x^{2}-5x-3}{x-4} by the reciprocal of \frac{-1}{x^{2}-16}.
\frac{\left(x-4\right)\left(x-3\right)\left(x+4\right)\left(2x+1\right)}{-\left(x-4\right)}
Factor the expressions that are not already factored.
\frac{\left(x-3\right)\left(x+4\right)\left(2x+1\right)}{-1}
Cancel out x-4 in both numerator and denominator.
-2x^{3}-3x^{2}+23x+12
Expand the expression.
\frac{\frac{2x^{2}-5x-3}{x-4}}{\frac{x-3}{\left(x^{2}-16\right)\left(3-x\right)}}
Multiply \frac{x-3}{x^{2}-16} times \frac{1}{3-x} by multiplying numerator times numerator and denominator times denominator.
\frac{\frac{2x^{2}-5x-3}{x-4}}{\frac{-\left(-x+3\right)}{\left(-x+3\right)\left(x^{2}-16\right)}}
Extract the negative sign in x-3.
\frac{\frac{2x^{2}-5x-3}{x-4}}{\frac{-1}{x^{2}-16}}
Cancel out -x+3 in both numerator and denominator.
\frac{\left(2x^{2}-5x-3\right)\left(x^{2}-16\right)}{\left(x-4\right)\left(-1\right)}
Divide \frac{2x^{2}-5x-3}{x-4} by \frac{-1}{x^{2}-16} by multiplying \frac{2x^{2}-5x-3}{x-4} by the reciprocal of \frac{-1}{x^{2}-16}.
\frac{\left(x-4\right)\left(x-3\right)\left(x+4\right)\left(2x+1\right)}{-\left(x-4\right)}
Factor the expressions that are not already factored.
\frac{\left(x-3\right)\left(x+4\right)\left(2x+1\right)}{-1}
Cancel out x-4 in both numerator and denominator.
-2x^{3}-3x^{2}+23x+12
Expand the expression.