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\left(-5\left(3yx^{3}-3x^{3}y+\frac{9x^{2}y}{9xy}\right)^{2}+5x^{2}\right)^{3}+\frac{\left(4xy\right)^{2}}{-4xy}
Cancel out 3yx^{3} in both numerator and denominator.
\left(-5\times \left(\frac{9x^{2}y}{9xy}\right)^{2}+5x^{2}\right)^{3}+\frac{\left(4xy\right)^{2}}{-4xy}
Combine 3yx^{3} and -3x^{3}y to get 0.
\left(-5x^{2}+5x^{2}\right)^{3}+\frac{\left(4xy\right)^{2}}{-4xy}
Cancel out 9xy in both numerator and denominator.
0^{3}+\frac{\left(4xy\right)^{2}}{-4xy}
Combine -5x^{2} and 5x^{2} to get 0.
0+\frac{\left(4xy\right)^{2}}{-4xy}
Calculate 0 to the power of 3 and get 0.
0+\frac{4^{2}x^{2}y^{2}}{-4xy}
Expand \left(4xy\right)^{2}.
0+\frac{16x^{2}y^{2}}{-4xy}
Calculate 4 to the power of 2 and get 16.
0+\frac{4xy}{-1}
Cancel out 4xy in both numerator and denominator.
0-4xy
Anything divided by -1 gives its opposite.
-4xy
Anything plus zero gives itself.
\left(-5\left(3yx^{3}-3x^{3}y+\frac{9x^{2}y}{9xy}\right)^{2}+5x^{2}\right)^{3}+\frac{\left(4xy\right)^{2}}{-4xy}
Cancel out 3yx^{3} in both numerator and denominator.
\left(-5\times \left(\frac{9x^{2}y}{9xy}\right)^{2}+5x^{2}\right)^{3}+\frac{\left(4xy\right)^{2}}{-4xy}
Combine 3yx^{3} and -3x^{3}y to get 0.
\left(-5x^{2}+5x^{2}\right)^{3}+\frac{\left(4xy\right)^{2}}{-4xy}
Cancel out 9xy in both numerator and denominator.
0^{3}+\frac{\left(4xy\right)^{2}}{-4xy}
Combine -5x^{2} and 5x^{2} to get 0.
0+\frac{\left(4xy\right)^{2}}{-4xy}
Calculate 0 to the power of 3 and get 0.
0+\frac{4^{2}x^{2}y^{2}}{-4xy}
Expand \left(4xy\right)^{2}.
0+\frac{16x^{2}y^{2}}{-4xy}
Calculate 4 to the power of 2 and get 16.
0+\frac{4xy}{-1}
Cancel out 4xy in both numerator and denominator.
0-4xy
Anything divided by -1 gives its opposite.
-4xy
Anything plus zero gives itself.