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\frac{\left(2^{4}\right)^{-2}}{\left(2^{2}\times 2\times 2^{3}\right)^{-2}}
To multiply powers of the same base, add their exponents. Add 1 and 3 to get 4.
\frac{2^{-8}}{\left(2^{2}\times 2\times 2^{3}\right)^{-2}}
To raise a power to another power, multiply the exponents. Multiply 4 and -2 to get -8.
\frac{2^{-8}}{\left(2^{3}\times 2^{3}\right)^{-2}}
To multiply powers of the same base, add their exponents. Add 2 and 1 to get 3.
\frac{2^{-8}}{\left(2^{6}\right)^{-2}}
To multiply powers of the same base, add their exponents. Add 3 and 3 to get 6.
\frac{2^{-8}}{2^{-12}}
To raise a power to another power, multiply the exponents. Multiply 6 and -2 to get -12.
2^{4}
To divide powers of the same base, subtract the denominator's exponent from the numerator's exponent. Subtract -12 from -8 to get 4.
16
Calculate 2 to the power of 4 and get 16.