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Differentiate w.r.t. a
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\left(8a^{-12}\right)^{1}\times \frac{1}{a^{5}}
Use the rules of exponents to simplify the expression.
8^{1}\left(a^{-12}\right)^{1}\times \frac{1}{1}\times \frac{1}{a^{5}}
To raise the product of two or more numbers to a power, raise each number to the power and take their product.
8^{1}\times \frac{1}{1}\left(a^{-12}\right)^{1}\times \frac{1}{a^{5}}
Use the Commutative Property of Multiplication.
8^{1}\times \frac{1}{1}a^{-12}a^{5\left(-1\right)}
To raise a power to another power, multiply the exponents.
8^{1}\times \frac{1}{1}a^{-12}a^{-5}
Multiply 5 times -1.
8^{1}\times \frac{1}{1}a^{-12-5}
To multiply powers of the same base, add their exponents.
8^{1}\times \frac{1}{1}a^{-17}
Add the exponents -12 and -5.
8\times \frac{1}{1}a^{-17}
Raise 8 to the power 1.
\frac{\mathrm{d}}{\mathrm{d}a}(\frac{8}{1}a^{-12-5})
To divide powers of the same base, subtract the denominator's exponent from the numerator's exponent.
\frac{\mathrm{d}}{\mathrm{d}a}(8a^{-17})
Do the arithmetic.
-17\times 8a^{-17-1}
The derivative of a polynomial is the sum of the derivatives of its terms. The derivative of a constant term is 0. The derivative of ax^{n} is nax^{n-1}.
-136a^{-18}
Do the arithmetic.