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Differentiate w.r.t. x
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\frac{\left(4x^{2}+1\right)\frac{\mathrm{d}}{\mathrm{d}x}(3x^{1})-3x^{1}\frac{\mathrm{d}}{\mathrm{d}x}(4x^{2}+1)}{\left(4x^{2}+1\right)^{2}}
For any two differentiable functions, the derivative of the quotient of two functions is the denominator times the derivative of the numerator minus the numerator times the derivative of the denominator, all divided by the denominator squared.
\frac{\left(4x^{2}+1\right)\times 3x^{1-1}-3x^{1}\times 2\times 4x^{2-1}}{\left(4x^{2}+1\right)^{2}}
The derivative of a polynomial is the sum of the derivatives of its terms. The derivative of a constant term is 0. The derivative of ax^{n} is nax^{n-1}.
\frac{\left(4x^{2}+1\right)\times 3x^{0}-3x^{1}\times 8x^{1}}{\left(4x^{2}+1\right)^{2}}
Do the arithmetic.
\frac{4x^{2}\times 3x^{0}+3x^{0}-3x^{1}\times 8x^{1}}{\left(4x^{2}+1\right)^{2}}
Expand using distributive property.
\frac{4\times 3x^{2}+3x^{0}-3\times 8x^{1+1}}{\left(4x^{2}+1\right)^{2}}
To multiply powers of the same base, add their exponents.
\frac{12x^{2}+3x^{0}-24x^{2}}{\left(4x^{2}+1\right)^{2}}
Do the arithmetic.
\frac{\left(12-24\right)x^{2}+3x^{0}}{\left(4x^{2}+1\right)^{2}}
Combine like terms.
\frac{-12x^{2}+3x^{0}}{\left(4x^{2}+1\right)^{2}}
Subtract 24 from 12.
\frac{3\left(-4x^{2}+x^{0}\right)}{\left(4x^{2}+1\right)^{2}}
Factor out 3.
\frac{3\left(-4x^{2}+1\right)}{\left(4x^{2}+1\right)^{2}}
For any term t except 0, t^{0}=1.