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Differentiate w.r.t. a
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\left(-a^{5}\right)^{1}\times \frac{1}{-a^{-3}}
Use the rules of exponents to simplify the expression.
-\left(a^{5}\right)^{1}\left(-1\right)\times \frac{1}{a^{-3}}
To raise the product of two or more numbers to a power, raise each number to the power and take their product.
-\left(-1\right)\left(a^{5}\right)^{1}\times \frac{1}{a^{-3}}
Use the Commutative Property of Multiplication.
-\left(-1\right)a^{5}a^{-3\left(-1\right)}
To raise a power to another power, multiply the exponents.
-\left(-1\right)a^{5}a^{3}
Multiply -3 times -1.
-\left(-1\right)a^{5+3}
To multiply powers of the same base, add their exponents.
-\left(-1\right)a^{8}
Add the exponents 5 and 3.
a^{8}
To multiply powers of the same base, add their exponents.
\frac{\mathrm{d}}{\mathrm{d}a}(\left(-\frac{1}{-1}\right)a^{5-\left(-3\right)})
To divide powers of the same base, subtract the denominator's exponent from the numerator's exponent.
\frac{\mathrm{d}}{\mathrm{d}a}(a^{8})
Do the arithmetic.
8a^{8-1}
The derivative of a polynomial is the sum of the derivatives of its terms. The derivative of a constant term is 0. The derivative of ax^{n} is nax^{n-1}.
8a^{7}
Do the arithmetic.