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Differentiate w.r.t. x
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\frac{\mathrm{d}}{\mathrm{d}x}(-2-5x^{4}-10x)
Subtract 4 from 2 to get -2.
4\left(-5\right)x^{4-1}-10x^{1-1}
The derivative of a polynomial is the sum of the derivatives of its terms. The derivative of a constant term is 0. The derivative of ax^{n} is nax^{n-1}.
-20x^{4-1}-10x^{1-1}
Multiply 4 times -5.
-20x^{3}-10x^{1-1}
Subtract 1 from 4.
-20x^{3}-10x^{0}
Subtract 1 from 1.
-20x^{3}-10
For any term t except 0, t^{0}=1.
-2-5x^{4}-10x
Subtract 4 from 2 to get -2.