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10x-250\times 3-450-5=-2\left(4\times 5+1\right)
Multiply both sides of the equation by 10, the least common multiple of 2,5.
10x-750-450-5=-2\left(4\times 5+1\right)
Multiply -250 and 3 to get -750.
10x-1200-5=-2\left(4\times 5+1\right)
Subtract 450 from -750 to get -1200.
10x-1205=-2\left(4\times 5+1\right)
Subtract 5 from -1200 to get -1205.
10x-1205=-2\left(20+1\right)
Multiply 4 and 5 to get 20.
10x-1205=-2\times 21
Add 20 and 1 to get 21.
10x-1205=-42
Multiply -2 and 21 to get -42.
10x=-42+1205
Add 1205 to both sides.
10x=1163
Add -42 and 1205 to get 1163.
x=\frac{1163}{10}
Divide both sides by 10.