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Differentiate w.r.t. x
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4x^{4-1}+6\times 3x^{6-1}-2x^{1-1}
The derivative of a polynomial is the sum of the derivatives of its terms. The derivative of a constant term is 0. The derivative of ax^{n} is nax^{n-1}.
4x^{3}+6\times 3x^{6-1}-2x^{1-1}
Subtract 1 from 4.
4x^{3}+18x^{6-1}-2x^{1-1}
Multiply 6 times 3.
4x^{3}+18x^{5}-2x^{1-1}
Subtract 1 from 6.
4x^{3}+18x^{5}-2x^{0}
Subtract 1 from 1.
4x^{3}+18x^{5}-2
For any term t except 0, t^{0}=1.