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Differentiate w.r.t. x
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\frac{\mathrm{d}}{\mathrm{d}x}(x^{-4})
Subtract 6 from 2 to get -4.
-4x^{-4-1}
The derivative of ax^{n} is nax^{n-1}.
-4x^{-5}
Subtract 1 from -4.
x^{-4}
Subtract 6 from 2 to get -4.