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x^{2}-8x\left(x-3y\right)+16\left(x^{2}-6xy+9y^{2}\right)
Use binomial theorem \left(a-b\right)^{2}=a^{2}-2ab+b^{2} to expand \left(x-3y\right)^{2}.
x^{2}-8x\left(x-3y\right)+16x^{2}-96xy+144y^{2}
Use the distributive property to multiply 16 by x^{2}-6xy+9y^{2}.
x^{2}-8x^{2}+24xy+16x^{2}-96xy+144y^{2}
Use the distributive property to multiply -8x by x-3y.
-7x^{2}+24xy+16x^{2}-96xy+144y^{2}
Combine x^{2} and -8x^{2} to get -7x^{2}.
9x^{2}+24xy-96xy+144y^{2}
Combine -7x^{2} and 16x^{2} to get 9x^{2}.
9x^{2}-72xy+144y^{2}
Combine 24xy and -96xy to get -72xy.
x^{2}-8x\left(x-3y\right)+16\left(x^{2}-6xy+9y^{2}\right)
Use binomial theorem \left(a-b\right)^{2}=a^{2}-2ab+b^{2} to expand \left(x-3y\right)^{2}.
x^{2}-8x\left(x-3y\right)+16x^{2}-96xy+144y^{2}
Use the distributive property to multiply 16 by x^{2}-6xy+9y^{2}.
x^{2}-8x^{2}+24xy+16x^{2}-96xy+144y^{2}
Use the distributive property to multiply -8x by x-3y.
-7x^{2}+24xy+16x^{2}-96xy+144y^{2}
Combine x^{2} and -8x^{2} to get -7x^{2}.
9x^{2}+24xy-96xy+144y^{2}
Combine -7x^{2} and 16x^{2} to get 9x^{2}.
9x^{2}-72xy+144y^{2}
Combine 24xy and -96xy to get -72xy.