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x^{2}+\frac{16^{2}}{x^{2}}=64
To raise \frac{16}{x} to a power, raise both numerator and denominator to the power and then divide.
\frac{x^{2}x^{2}}{x^{2}}+\frac{16^{2}}{x^{2}}=64
To add or subtract expressions, expand them to make their denominators the same. Multiply x^{2} times \frac{x^{2}}{x^{2}}.
\frac{x^{2}x^{2}+16^{2}}{x^{2}}=64
Since \frac{x^{2}x^{2}}{x^{2}} and \frac{16^{2}}{x^{2}} have the same denominator, add them by adding their numerators.
\frac{x^{4}+16^{2}}{x^{2}}=64
Do the multiplications in x^{2}x^{2}+16^{2}.
\frac{x^{4}+256}{x^{2}}=64
Combine like terms in x^{4}+16^{2}.
\frac{x^{4}+256}{x^{2}}-64=0
Subtract 64 from both sides.
\frac{x^{4}+256}{x^{2}}-\frac{64x^{2}}{x^{2}}=0
To add or subtract expressions, expand them to make their denominators the same. Multiply 64 times \frac{x^{2}}{x^{2}}.
\frac{x^{4}+256-64x^{2}}{x^{2}}=0
Since \frac{x^{4}+256}{x^{2}} and \frac{64x^{2}}{x^{2}} have the same denominator, subtract them by subtracting their numerators.
x^{4}+256-64x^{2}=0
Variable x cannot be equal to 0 since division by zero is not defined. Multiply both sides of the equation by x^{2}.
t^{2}-64t+256=0
Substitute t for x^{2}.
t=\frac{-\left(-64\right)±\sqrt{\left(-64\right)^{2}-4\times 1\times 256}}{2}
All equations of the form ax^{2}+bx+c=0 can be solved using the quadratic formula: \frac{-b±\sqrt{b^{2}-4ac}}{2a}. Substitute 1 for a, -64 for b, and 256 for c in the quadratic formula.
t=\frac{64±32\sqrt{3}}{2}
Do the calculations.
t=16\sqrt{3}+32 t=32-16\sqrt{3}
Solve the equation t=\frac{64±32\sqrt{3}}{2} when ± is plus and when ± is minus.
x=2\sqrt{2}+2\sqrt{6} x=-\left(2\sqrt{2}+2\sqrt{6}\right) x=-\left(2\sqrt{2}-2\sqrt{6}\right) x=2\sqrt{2}-2\sqrt{6}
Since x=t^{2}, the solutions are obtained by evaluating x=±\sqrt{t} for each t.