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3\left(x^{2}+8x+16\right)\left(4x-1\right)\left(x-5\right)^{2}
Use binomial theorem \left(a+b\right)^{2}=a^{2}+2ab+b^{2} to expand \left(x+4\right)^{2}.
3\left(x^{2}+8x+16\right)\left(4x-1\right)\left(x^{2}-10x+25\right)
Use binomial theorem \left(a-b\right)^{2}=a^{2}-2ab+b^{2} to expand \left(x-5\right)^{2}.
\left(3x^{2}+24x+48\right)\left(4x-1\right)\left(x^{2}-10x+25\right)
Use the distributive property to multiply 3 by x^{2}+8x+16.
\left(12x^{3}+93x^{2}+168x-48\right)\left(x^{2}-10x+25\right)
Use the distributive property to multiply 3x^{2}+24x+48 by 4x-1 and combine like terms.
12x^{5}-27x^{4}-462x^{3}+597x^{2}+4680x-1200
Use the distributive property to multiply 12x^{3}+93x^{2}+168x-48 by x^{2}-10x+25 and combine like terms.
3\left(x^{2}+8x+16\right)\left(4x-1\right)\left(x-5\right)^{2}
Use binomial theorem \left(a+b\right)^{2}=a^{2}+2ab+b^{2} to expand \left(x+4\right)^{2}.
3\left(x^{2}+8x+16\right)\left(4x-1\right)\left(x^{2}-10x+25\right)
Use binomial theorem \left(a-b\right)^{2}=a^{2}-2ab+b^{2} to expand \left(x-5\right)^{2}.
\left(3x^{2}+24x+48\right)\left(4x-1\right)\left(x^{2}-10x+25\right)
Use the distributive property to multiply 3 by x^{2}+8x+16.
\left(12x^{3}+93x^{2}+168x-48\right)\left(x^{2}-10x+25\right)
Use the distributive property to multiply 3x^{2}+24x+48 by 4x-1 and combine like terms.
12x^{5}-27x^{4}-462x^{3}+597x^{2}+4680x-1200
Use the distributive property to multiply 12x^{3}+93x^{2}+168x-48 by x^{2}-10x+25 and combine like terms.