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Differentiate w.r.t. x
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4\left(-1\right)x^{4-1}+3\left(-4\right)x^{3-1}+6x^{1-1}
The derivative of a polynomial is the sum of the derivatives of its terms. The derivative of a constant term is 0. The derivative of ax^{n} is nax^{n-1}.
-4x^{4-1}+3\left(-4\right)x^{3-1}+6x^{1-1}
Multiply 4 times -1.
-4x^{3}+3\left(-4\right)x^{3-1}+6x^{1-1}
Subtract 1 from 4.
-4x^{3}-12x^{3-1}+6x^{1-1}
Multiply 3 times -4.
-4x^{3}-12x^{2}+6x^{1-1}
Subtract 1 from 3.
-4x^{3}-12x^{2}+6x^{0}
Subtract 1 from 1.
-4x^{3}-12x^{2}+6\times 1
For any term t except 0, t^{0}=1.
-4x^{3}-12x^{2}+6
For any term t, t\times 1=t and 1t=t.