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Differentiate w.r.t. x
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-\left(x^{2}+4x^{1}+4\right)^{-1-1}\frac{\mathrm{d}}{\mathrm{d}x}(x^{2}+4x^{1}+4)
If F is the composition of two differentiable functions f\left(u\right) and u=g\left(x\right), that is, if F\left(x\right)=f\left(g\left(x\right)\right), then the derivative of F is the derivative of f with respect to u times the derivative of g with respect to x, that is, \frac{\mathrm{d}}{\mathrm{d}x}(F)\left(x\right)=\frac{\mathrm{d}}{\mathrm{d}x}(f)\left(g\left(x\right)\right)\frac{\mathrm{d}}{\mathrm{d}x}(g)\left(x\right).
-\left(x^{2}+4x^{1}+4\right)^{-2}\left(2x^{2-1}+4x^{1-1}\right)
The derivative of a polynomial is the sum of the derivatives of its terms. The derivative of a constant term is 0. The derivative of ax^{n} is nax^{n-1}.
\left(x^{2}+4x^{1}+4\right)^{-2}\left(-2x^{1}-4x^{0}\right)
Simplify.
\left(x^{2}+4x+4\right)^{-2}\left(-2x-4x^{0}\right)
For any term t, t^{1}=t.
\left(x^{2}+4x+4\right)^{-2}\left(-2x-4\right)
For any term t except 0, t^{0}=1.