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Differentiate w.r.t. x
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5\times 2x^{5-1}+3\times 4x^{3-1}+2\left(-25\right)x^{2-1}
The derivative of a polynomial is the sum of the derivatives of its terms. The derivative of a constant term is 0. The derivative of ax^{n} is nax^{n-1}.
10x^{5-1}+3\times 4x^{3-1}+2\left(-25\right)x^{2-1}
Multiply 5 times 2.
10x^{4}+3\times 4x^{3-1}+2\left(-25\right)x^{2-1}
Subtract 1 from 5.
10x^{4}+12x^{3-1}+2\left(-25\right)x^{2-1}
Multiply 3 times 4.
10x^{4}+12x^{2}+2\left(-25\right)x^{2-1}
Subtract 1 from 3.
10x^{4}+12x^{2}-50x^{2-1}
Multiply 3 times 4.
10x^{4}+12x^{2}-50x^{1}
Subtract 1 from 2.
10x^{4}+12x^{2}-50x
For any term t, t^{1}=t.