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E=\left(2z\right)^{2}\left(z+1\right)\left(z+3\right)-5z\left(z+4\right)-27
Combine z and z to get 2z.
E=2^{2}z^{2}\left(z+1\right)\left(z+3\right)-5z\left(z+4\right)-27
Expand \left(2z\right)^{2}.
E=4z^{2}\left(z+1\right)\left(z+3\right)-5z\left(z+4\right)-27
Calculate 2 to the power of 2 and get 4.
E=\left(4z^{3}+4z^{2}\right)\left(z+3\right)-5z\left(z+4\right)-27
Use the distributive property to multiply 4z^{2} by z+1.
E=4z^{4}+16z^{3}+12z^{2}-5z\left(z+4\right)-27
Use the distributive property to multiply 4z^{3}+4z^{2} by z+3 and combine like terms.
E=4z^{4}+16z^{3}+12z^{2}-5z^{2}-20z-27
Use the distributive property to multiply -5z by z+4.
E=4z^{4}+16z^{3}+7z^{2}-20z-27
Combine 12z^{2} and -5z^{2} to get 7z^{2}.