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E=\frac{\frac{35184372088832\left(-4\right)^{5}}{\left(-8\right)^{5}}}{2^{6}}
Calculate 2 to the power of 45 and get 35184372088832.
E=\frac{\frac{35184372088832\left(-1024\right)}{\left(-8\right)^{5}}}{2^{6}}
Calculate -4 to the power of 5 and get -1024.
E=\frac{\frac{-36028797018963968}{\left(-8\right)^{5}}}{2^{6}}
Multiply 35184372088832 and -1024 to get -36028797018963968.
E=\frac{\frac{-36028797018963968}{-32768}}{2^{6}}
Calculate -8 to the power of 5 and get -32768.
E=\frac{1099511627776}{2^{6}}
Divide -36028797018963968 by -32768 to get 1099511627776.
E=\frac{1099511627776}{64}
Calculate 2 to the power of 6 and get 64.
E=17179869184
Divide 1099511627776 by 64 to get 17179869184.