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Differentiate w.r.t. c
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4\times 4c^{4-1}
The derivative of a polynomial is the sum of the derivatives of its terms. The derivative of a constant term is 0. The derivative of ax^{n} is nax^{n-1}.
16c^{4-1}
Multiply 4 times 4.
16c^{3}
Subtract 1 from 4.