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4\left(p^{2}+8p+16\right)-\left(7p+2q\right)^{2}
Use binomial theorem \left(a+b\right)^{2}=a^{2}+2ab+b^{2} to expand \left(p+4\right)^{2}.
4p^{2}+32p+64-\left(7p+2q\right)^{2}
Use the distributive property to multiply 4 by p^{2}+8p+16.
4p^{2}+32p+64-\left(49p^{2}+28pq+4q^{2}\right)
Use binomial theorem \left(a+b\right)^{2}=a^{2}+2ab+b^{2} to expand \left(7p+2q\right)^{2}.
4p^{2}+32p+64-49p^{2}-28pq-4q^{2}
To find the opposite of 49p^{2}+28pq+4q^{2}, find the opposite of each term.
-45p^{2}+32p+64-28pq-4q^{2}
Combine 4p^{2} and -49p^{2} to get -45p^{2}.
4\left(p^{2}+8p+16\right)-\left(7p+2q\right)^{2}
Use binomial theorem \left(a+b\right)^{2}=a^{2}+2ab+b^{2} to expand \left(p+4\right)^{2}.
4p^{2}+32p+64-\left(7p+2q\right)^{2}
Use the distributive property to multiply 4 by p^{2}+8p+16.
4p^{2}+32p+64-\left(49p^{2}+28pq+4q^{2}\right)
Use binomial theorem \left(a+b\right)^{2}=a^{2}+2ab+b^{2} to expand \left(7p+2q\right)^{2}.
4p^{2}+32p+64-49p^{2}-28pq-4q^{2}
To find the opposite of 49p^{2}+28pq+4q^{2}, find the opposite of each term.
-45p^{2}+32p+64-28pq-4q^{2}
Combine 4p^{2} and -49p^{2} to get -45p^{2}.