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Differentiate w.r.t. x
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\frac{\mathrm{d}}{\mathrm{d}x}(-21x^{2})
Combine 4x^{2} and -25x^{2} to get -21x^{2}.
2\left(-21\right)x^{2-1}
The derivative of ax^{n} is nax^{n-1}.
-42x^{2-1}
Multiply 2 times -21.
-42x^{1}
Subtract 1 from 2.
-42x
For any term t, t^{1}=t.
-21x^{2}
Combine 4x^{2} and -25x^{2} to get -21x^{2}.