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Differentiate w.r.t. x
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5\left(-2\right)x^{5-1}+3\times 6x^{3-1}+6\left(-4\right)x^{6-1}
The derivative of a polynomial is the sum of the derivatives of its terms. The derivative of a constant term is 0. The derivative of ax^{n} is nax^{n-1}.
-10x^{5-1}+3\times 6x^{3-1}+6\left(-4\right)x^{6-1}
Multiply 5 times -2.
-10x^{4}+3\times 6x^{3-1}+6\left(-4\right)x^{6-1}
Subtract 1 from 5.
-10x^{4}+18x^{3-1}+6\left(-4\right)x^{6-1}
Multiply 3 times 6.
-10x^{4}+18x^{2}+6\left(-4\right)x^{6-1}
Subtract 1 from 3.
-10x^{4}+18x^{2}-24x^{6-1}
Multiply 3 times 6.
-10x^{4}+18x^{2}-24x^{5}
Subtract 1 from 6.