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2\left(xy^{2}x^{3}+16xy^{2}x^{2}+64xy^{2}x-4x^{3}-64x^{2}-256x\right)
Factor out 2.
x\left(y^{2}x^{3}+16y^{2}x^{2}+64y^{2}x-4x^{2}-64x-256\right)
Consider y^{2}x^{4}+16y^{2}x^{3}+64y^{2}x^{2}-4x^{3}-64x^{2}-256x. Factor out x.
xy^{2}\left(x^{2}+16x+64\right)-4\left(x^{2}+16x+64\right)
Consider y^{2}x^{3}+16y^{2}x^{2}+64y^{2}x-4x^{2}-64x-256. Do the grouping y^{2}x^{3}+16y^{2}x^{2}+64y^{2}x-4x^{2}-64x-256=\left(y^{2}x^{3}+16y^{2}x^{2}+64y^{2}x\right)+\left(-4x^{2}-64x-256\right), and factor out xy^{2} in the first and -4 in the second group.
\left(x^{2}+16x+64\right)\left(xy^{2}-4\right)
Factor out common term x^{2}+16x+64 by using distributive property.
\left(x+8\right)^{2}
Consider x^{2}+16x+64. Use the perfect square formula, a^{2}+2ab+b^{2}=\left(a+b\right)^{2}, where a=x and b=8.
2x\left(x+8\right)^{2}\left(xy^{2}-4\right)
Rewrite the complete factored expression.