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Differentiate w.r.t. x
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2\times 2x^{2-1}+8\left(-4\right)x^{8-1}
The derivative of a polynomial is the sum of the derivatives of its terms. The derivative of a constant term is 0. The derivative of ax^{n} is nax^{n-1}.
4x^{2-1}+8\left(-4\right)x^{8-1}
Multiply 2 times 2.
4x^{1}+8\left(-4\right)x^{8-1}
Subtract 1 from 2.
4x^{1}-32x^{8-1}
Multiply 8 times -4.
4x^{1}-32x^{7}
Subtract 1 from 8.
4x-32x^{7}
For any term t, t^{1}=t.