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Differentiate w.r.t. x
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\frac{\mathrm{d}}{\mathrm{d}x}(16x^{3})
Multiply 2 and 8 to get 16.
3\times 16x^{3-1}
The derivative of ax^{n} is nax^{n-1}.
48x^{3-1}
Multiply 3 times 16.
48x^{2}
Subtract 1 from 3.
16x^{3}
Multiply 2 and 8 to get 16.