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Differentiate w.r.t. y
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2\times 2y^{2-1}-250y^{1-1}
The derivative of a polynomial is the sum of the derivatives of its terms. The derivative of a constant term is 0. The derivative of ax^{n} is nax^{n-1}.
4y^{2-1}-250y^{1-1}
Multiply 2 times 2.
4y^{1}-250y^{1-1}
Subtract 1 from 2.
4y^{1}-250y^{0}
Subtract 1 from 1.
4y-250y^{0}
For any term t, t^{1}=t.
4y-250
For any term t except 0, t^{0}=1.