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16-\left(\left(-a\right)^{2}+3\left(-a\right)\right)\times 4<0
Use the distributive property to multiply -a by -a+3.
16-\left(a^{2}+3\left(-a\right)\right)\times 4<0
Calculate -a to the power of 2 and get a^{2}.
16-\left(4a^{2}+12\left(-a\right)\right)<0
Use the distributive property to multiply a^{2}+3\left(-a\right) by 4.
16-4a^{2}-12\left(-a\right)<0
To find the opposite of 4a^{2}+12\left(-a\right), find the opposite of each term.
16-4a^{2}+12a<0
Multiply -12 and -1 to get 12.
-16+4a^{2}-12a>0
Multiply the inequality by -1 to make the coefficient of the highest power in 16-4a^{2}+12a positive. Since -1 is negative, the inequality direction is changed.
-16+4a^{2}-12a=0
To solve the inequality, factor the left hand side. Quadratic polynomial can be factored using the transformation ax^{2}+bx+c=a\left(x-x_{1}\right)\left(x-x_{2}\right), where x_{1} and x_{2} are the solutions of the quadratic equation ax^{2}+bx+c=0.
a=\frac{-\left(-12\right)±\sqrt{\left(-12\right)^{2}-4\times 4\left(-16\right)}}{2\times 4}
All equations of the form ax^{2}+bx+c=0 can be solved using the quadratic formula: \frac{-b±\sqrt{b^{2}-4ac}}{2a}. Substitute 4 for a, -12 for b, and -16 for c in the quadratic formula.
a=\frac{12±20}{8}
Do the calculations.
a=4 a=-1
Solve the equation a=\frac{12±20}{8} when ± is plus and when ± is minus.
4\left(a-4\right)\left(a+1\right)>0
Rewrite the inequality by using the obtained solutions.
a-4<0 a+1<0
For the product to be positive, a-4 and a+1 have to be both negative or both positive. Consider the case when a-4 and a+1 are both negative.
a<-1
The solution satisfying both inequalities is a<-1.
a+1>0 a-4>0
Consider the case when a-4 and a+1 are both positive.
a>4
The solution satisfying both inequalities is a>4.
a<-1\text{; }a>4
The final solution is the union of the obtained solutions.