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144\left(\frac{3}{12}-\frac{5}{12}\right)
Least common multiple of 4 and 12 is 12. Convert \frac{1}{4} and \frac{5}{12} to fractions with denominator 12.
144\times \frac{3-5}{12}
Since \frac{3}{12} and \frac{5}{12} have the same denominator, subtract them by subtracting their numerators.
144\times \frac{-2}{12}
Subtract 5 from 3 to get -2.
144\left(-\frac{1}{6}\right)
Reduce the fraction \frac{-2}{12} to lowest terms by extracting and canceling out 2.
\frac{144\left(-1\right)}{6}
Express 144\left(-\frac{1}{6}\right) as a single fraction.
\frac{-144}{6}
Multiply 144 and -1 to get -144.
-24
Divide -144 by 6 to get -24.