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48+12x-\left(16+4x+48+8x\right)
Use the distributive property to multiply 12 by 4+x.
48+12x-\left(64+4x+8x\right)
Add 16 and 48 to get 64.
48+12x-\left(64+12x\right)
Combine 4x and 8x to get 12x.
48+12x-64-12x
To find the opposite of 64+12x, find the opposite of each term.
-16+12x-12x
Subtract 64 from 48 to get -16.
-16
Combine 12x and -12x to get 0.
4\left(3\left(4+x\right)-\left(16+3x\right)\right)
Factor out 4.
-16
Simplify.