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Differentiate w.r.t. x
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\frac{\mathrm{d}}{\mathrm{d}x}(\frac{-10}{x})
Express 10\left(-\frac{1}{x}\right) as a single fraction.
-\left(-10\right)x^{-1-1}
The derivative of ax^{n} is nax^{n-1}.
10x^{-1-1}
Multiply -1 times -10.
10x^{-2}
Subtract 1 from -1.
\frac{-10}{x}
Express 10\left(-\frac{1}{x}\right) as a single fraction.