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Differentiate w.r.t. x
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\frac{2}{3}\left(-1\right)x^{\frac{2}{3}-1}
The derivative of a polynomial is the sum of the derivatives of its terms. The derivative of a constant term is 0. The derivative of ax^{n} is nax^{n-1}.
-\frac{2}{3}x^{\frac{2}{3}-1}
Multiply \frac{2}{3} times -1.
-\frac{2}{3}x^{-\frac{1}{3}}
Subtract 1 from \frac{2}{3}.