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-4\sqrt{16-\frac{4\times 2\left(-16\right)}{2}\times 2}
Calculate 4 to the power of 2 and get 16.
-4\sqrt{16-4\left(-16\right)\times 2}
Cancel out 2 and 2.
-4\sqrt{16-\left(-64\times 2\right)}
Multiply 4 and -16 to get -64.
-4\sqrt{16-\left(-128\right)}
Multiply -64 and 2 to get -128.
-4\sqrt{16+128}
The opposite of -128 is 128.
-4\sqrt{144}
Add 16 and 128 to get 144.
-4\times 12
Calculate the square root of 144 and get 12.
-48
Multiply -4 and 12 to get -48.