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-16\left(4-2\right)-\frac{1}{8}\times \frac{1}{64}\times \frac{1}{4}\times \frac{1}{100}
Multiply 2 and 1 to get 2.
-16\times 2-\frac{1}{8}\times \frac{1}{64}\times \frac{1}{4}\times \frac{1}{100}
Subtract 2 from 4 to get 2.
-32-\frac{1}{8}\times \frac{1}{64}\times \frac{1}{4}\times \frac{1}{100}
Multiply -16 and 2 to get -32.
-32-\frac{1\times 1}{8\times 64}\times \frac{1}{4}\times \frac{1}{100}
Multiply \frac{1}{8} times \frac{1}{64} by multiplying numerator times numerator and denominator times denominator.
-32-\frac{1}{512}\times \frac{1}{4}\times \frac{1}{100}
Do the multiplications in the fraction \frac{1\times 1}{8\times 64}.
-32-\frac{1\times 1}{512\times 4}\times \frac{1}{100}
Multiply \frac{1}{512} times \frac{1}{4} by multiplying numerator times numerator and denominator times denominator.
-32-\frac{1}{2048}\times \frac{1}{100}
Do the multiplications in the fraction \frac{1\times 1}{512\times 4}.
-32-\frac{1\times 1}{2048\times 100}
Multiply \frac{1}{2048} times \frac{1}{100} by multiplying numerator times numerator and denominator times denominator.
-32-\frac{1}{204800}
Do the multiplications in the fraction \frac{1\times 1}{2048\times 100}.
-\frac{6553600}{204800}-\frac{1}{204800}
Convert -32 to fraction -\frac{6553600}{204800}.
\frac{-6553600-1}{204800}
Since -\frac{6553600}{204800} and \frac{1}{204800} have the same denominator, subtract them by subtracting their numerators.
-\frac{6553601}{204800}
Subtract 1 from -6553600 to get -6553601.