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\left(-x^{3}\right)y^{-4}\times 2^{4}\left(x^{-2}\right)^{4}\left(y^{5}\right)^{4}
Expand \left(2x^{-2}y^{5}\right)^{4}.
\left(-x^{3}\right)y^{-4}\times 2^{4}x^{-8}\left(y^{5}\right)^{4}
To raise a power to another power, multiply the exponents. Multiply -2 and 4 to get -8.
\left(-x^{3}\right)y^{-4}\times 2^{4}x^{-8}y^{20}
To raise a power to another power, multiply the exponents. Multiply 5 and 4 to get 20.
\left(-x^{3}\right)y^{-4}\times 16x^{-8}y^{20}
Calculate 2 to the power of 4 and get 16.
\left(-x^{3}\right)y^{16}\times 16x^{-8}
To multiply powers of the same base, add their exponents. Add -4 and 20 to get 16.
-16x^{3}y^{16}x^{-8}
Multiply -1 and 16 to get -16.
-16x^{-5}y^{16}
To multiply powers of the same base, add their exponents. Add 3 and -8 to get -5.
\left(-x^{3}\right)y^{-4}\times 2^{4}\left(x^{-2}\right)^{4}\left(y^{5}\right)^{4}
Expand \left(2x^{-2}y^{5}\right)^{4}.
\left(-x^{3}\right)y^{-4}\times 2^{4}x^{-8}\left(y^{5}\right)^{4}
To raise a power to another power, multiply the exponents. Multiply -2 and 4 to get -8.
\left(-x^{3}\right)y^{-4}\times 2^{4}x^{-8}y^{20}
To raise a power to another power, multiply the exponents. Multiply 5 and 4 to get 20.
\left(-x^{3}\right)y^{-4}\times 16x^{-8}y^{20}
Calculate 2 to the power of 4 and get 16.
\left(-x^{3}\right)y^{16}\times 16x^{-8}
To multiply powers of the same base, add their exponents. Add -4 and 20 to get 16.
-16x^{3}y^{16}x^{-8}
Multiply -1 and 16 to get -16.
-16x^{-5}y^{16}
To multiply powers of the same base, add their exponents. Add 3 and -8 to get -5.