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Differentiate w.r.t. x
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16\left(-1\right)x^{16-1}
The derivative of a polynomial is the sum of the derivatives of its terms. The derivative of a constant term is 0. The derivative of ax^{n} is nax^{n-1}.
-16x^{16-1}
Multiply 16 times -1.
-16x^{15}
Subtract 1 from 16.