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\left(4c^{3}+ab\right)\left(4c^{3}-ab\right)
Rewrite -a^{2}b^{2}+16c^{6} as \left(4c^{3}\right)^{2}-\left(-ab\right)^{2}. The difference of squares can be factored using the rule: p^{2}-q^{2}=\left(p-q\right)\left(p+q\right).
\left(ab+4c^{3}\right)\left(-ab+4c^{3}\right)
Reorder the terms.