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-\frac{360+54}{72}+\frac{4\times 72+24}{72}-\frac{6\times 72+54}{72}
Multiply 5 and 72 to get 360.
-\frac{414}{72}+\frac{4\times 72+24}{72}-\frac{6\times 72+54}{72}
Add 360 and 54 to get 414.
-\frac{23}{4}+\frac{4\times 72+24}{72}-\frac{6\times 72+54}{72}
Reduce the fraction \frac{414}{72} to lowest terms by extracting and canceling out 18.
-\frac{23}{4}+\frac{288+24}{72}-\frac{6\times 72+54}{72}
Multiply 4 and 72 to get 288.
-\frac{23}{4}+\frac{312}{72}-\frac{6\times 72+54}{72}
Add 288 and 24 to get 312.
-\frac{23}{4}+\frac{13}{3}-\frac{6\times 72+54}{72}
Reduce the fraction \frac{312}{72} to lowest terms by extracting and canceling out 24.
-\frac{69}{12}+\frac{52}{12}-\frac{6\times 72+54}{72}
Least common multiple of 4 and 3 is 12. Convert -\frac{23}{4} and \frac{13}{3} to fractions with denominator 12.
\frac{-69+52}{12}-\frac{6\times 72+54}{72}
Since -\frac{69}{12} and \frac{52}{12} have the same denominator, add them by adding their numerators.
-\frac{17}{12}-\frac{6\times 72+54}{72}
Add -69 and 52 to get -17.
-\frac{17}{12}-\frac{432+54}{72}
Multiply 6 and 72 to get 432.
-\frac{17}{12}-\frac{486}{72}
Add 432 and 54 to get 486.
-\frac{17}{12}-\frac{27}{4}
Reduce the fraction \frac{486}{72} to lowest terms by extracting and canceling out 18.
-\frac{17}{12}-\frac{81}{12}
Least common multiple of 12 and 4 is 12. Convert -\frac{17}{12} and \frac{27}{4} to fractions with denominator 12.
\frac{-17-81}{12}
Since -\frac{17}{12} and \frac{81}{12} have the same denominator, subtract them by subtracting their numerators.
\frac{-98}{12}
Subtract 81 from -17 to get -98.
-\frac{49}{6}
Reduce the fraction \frac{-98}{12} to lowest terms by extracting and canceling out 2.