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Differentiate w.r.t. x
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\left(-4x^{2}\right)^{1}\times \frac{1}{x^{3}}
Use the rules of exponents to simplify the expression.
\left(-4\right)^{1}\left(x^{2}\right)^{1}\times \frac{1}{1}\times \frac{1}{x^{3}}
To raise the product of two or more numbers to a power, raise each number to the power and take their product.
\left(-4\right)^{1}\times \frac{1}{1}\left(x^{2}\right)^{1}\times \frac{1}{x^{3}}
Use the Commutative Property of Multiplication.
\left(-4\right)^{1}\times \frac{1}{1}x^{2}x^{3\left(-1\right)}
To raise a power to another power, multiply the exponents.
\left(-4\right)^{1}\times \frac{1}{1}x^{2}x^{-3}
Multiply 3 times -1.
\left(-4\right)^{1}\times \frac{1}{1}x^{2-3}
To multiply powers of the same base, add their exponents.
\left(-4\right)^{1}\times \frac{1}{1}\times \frac{1}{x}
Add the exponents 2 and -3.
-4\times \frac{1}{1}\times \frac{1}{x}
Raise -4 to the power 1.
\frac{\mathrm{d}}{\mathrm{d}x}(\left(-\frac{4}{1}\right)x^{2-3})
To divide powers of the same base, subtract the denominator's exponent from the numerator's exponent.
\frac{\mathrm{d}}{\mathrm{d}x}(-4\times \frac{1}{x})
Do the arithmetic.
-\left(-4\right)x^{-1-1}
The derivative of a polynomial is the sum of the derivatives of its terms. The derivative of a constant term is 0. The derivative of ax^{n} is nax^{n-1}.
4x^{-2}
Do the arithmetic.