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2\left(-x^{3}+4x^{2}-4x+16\right)
Factor out 2.
x^{2}\left(-x+4\right)+4\left(-x+4\right)
Consider -x^{3}+4x^{2}-4x+16. Do the grouping -x^{3}+4x^{2}-4x+16=\left(-x^{3}+4x^{2}\right)+\left(-4x+16\right), and factor out x^{2} in the first and 4 in the second group.
\left(-x+4\right)\left(x^{2}+4\right)
Factor out common term -x+4 by using distributive property.
2\left(-x+4\right)\left(x^{2}+4\right)
Rewrite the complete factored expression. Polynomial x^{2}+4 is not factored since it does not have any rational roots.