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Differentiate w.r.t. q
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\frac{\mathrm{d}}{\mathrm{d}q}(-10q^{4})
Combine -2q^{4} and -8q^{4} to get -10q^{4}.
4\left(-10\right)q^{4-1}
The derivative of ax^{n} is nax^{n-1}.
-40q^{4-1}
Multiply 4 times -10.
-40q^{3}
Subtract 1 from 4.
-10q^{4}
Combine -2q^{4} and -8q^{4} to get -10q^{4}.