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Differentiate w.r.t. x
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\frac{\mathrm{d}}{\mathrm{d}x}(-x^{12})
To raise a power to another power, multiply the exponents. Multiply 4 and 3 to get 12.
12\left(-1\right)x^{12-1}
The derivative of ax^{n} is nax^{n-1}.
-12x^{12-1}
Multiply 12 times -1.
-12x^{11}
Subtract 1 from 12.